Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methicillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | RARG | P13631 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methicillin SCHEMBL10743888 | 1.00 | PTGS1 (0.98) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL34136 | 1.00 | PTGS1 (0.98) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL15544897 | 0.99 | PTGS1 (1.00) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL30686387 | 0.99 | PTGS1 (1.00) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL4548766 | 0.99 | PTGS1 (1.00) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL6930787 | 0.99 | PTGS1 (1.00) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL4898 | 0.99 | PTGS1 (1.00) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL28422658 | 0.98 | PTGS1 (0.98) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL29184234 | 0.98 | PTGS1 (0.98) | PTGS1PDE3ALMNAABCB11HRH1 | |
| Methicillin SCHEMBL28861820 | 0.97 | PTGS1 (0.96) | PTGS1PDE3ALMNAABCB11HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083484-A1 | 1,1-Alkanediol dicarboxylate linked antibacterial agents | PFIZER INC. (US) | 1983-07-13 | — | — | EP | disclosed |