Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231466 | 0.92 | CYP3A4 (0.45) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL5588513 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| Phosphine SCHEMBL28045431 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL4257325 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL29598351 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL11551492 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL11530312 | 0.90 | CYP3A4 (0.43) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL11729004 | 0.88 | CYP3A4 (0.38) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL1984766 | 0.88 | CYP3A4 (0.38) | CYP3A4TDP1TP53ESR1ESR2 | |
| SCHEMBL7784620 | 0.88 | CYP3A4 (0.38) | CYP3A4TDP1TP53ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003897-B1 | PHOSPHINEGOLD(I)SALTS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-05-25 | — | — | EP | disclosed |
| EP-0003897-A1 | Phosphinegold(I)salts, process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-09-05 | — | — | EP | disclosed |
| US-4096250-A | ANTI-ARTHRITIC | SMITHKLINE CORPORATION (US) | 1978-06-20 | — | — | US | disclosed |
| US-3947565-A | Anti-arthritic compositions comprising s-heterocyclic derivatives of phosphine or phosphite gold mercaptides and methods of producing anti-arthritic activity | SMITHKLINE CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |