Tebutam

Tebutam

SCHEMBL11209192

CC(C)N(Cc1ccccc1)C(=O)C(C)(C)C

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.65
KMT2A Q03164 3/20 0.65
TSHR P16473 2/20 0.56
POLB P06746 2/20 0.50
ATM Q13315 1/20 0.49
PSEN1 P49768 1/20 0.49
PSEN2 P49810 1/20 0.49
APH1B Q8WW43 1/20 0.49
NCSTN Q92542 1/20 0.49
APH1A Q96BI3 1/20 0.49
PSENEN Q9NZ42 1/20 0.49
RIPK1 Q13546 2/20 0.49
ALDH1A1 P00352 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 1/20 0.46
RECQL P46063 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tebutam SCHEMBL8539325 1.00 MEN1 (0.65) MEN1KMT2ATSHRPOLBATM
Tebutam SCHEMBL63650 1.00 MEN1 (0.65) MEN1KMT2ATSHRPOLBATM
SCHEMBL18701561 0.85 MEN1 (0.51) MEN1KMT2ATSHRPOLBRIPK1
SCHEMBL18701729 0.85 MEN1 (0.51) MEN1KMT2ATSHRPOLBRIPK1
SCHEMBL1701279 0.83 KMT2A (0.76) MEN1KMT2ATSHRPOLBATM
SCHEMBL27334284 0.83 MEN1 (0.53) MEN1KMT2ATSHRPOLBALDH1A1
SCHEMBL13167408 0.82 KMT2A (0.69) MEN1KMT2ATSHRPOLBATM
SCHEMBL28705761 0.82 RECQL (0.58) MEN1KMT2ATSHRPOLBRIPK1
SCHEMBL7772334 0.80 KMT2A (0.71) MEN1KMT2ATSHRPOLBATM
SCHEMBL25852384 0.80 KMT2A (0.71) MEN1KMT2APOLBATMPSEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0044979-B1 DERIVATIVES OF 2-FLUORO-ALKANECARBOXYLIC ACIDS, THEIR PREPARATION, HERBICIDES COMPRISING THEM AND THEIR APPLICATION BASF Aktiengesellschaft (DE) 1983-11-02 EP disclosed
EP-0032242-A1 4H-3,1-benzoxazine derivatives, process for their preparation and their use in inhibiting the growth of unwanted plants BASF Aktiengesellschaft (DE) 1981-07-22 EP disclosed