Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20711333 | 0.85 | TRPV1 (0.47) | TRPV1CNR2CNR1PKMATM | |
| SCHEMBL4409005 | 0.76 | TRPV1 (0.53) | TRPV1CNR2CNR1PKMATM | |
| SCHEMBL14417090 | 0.75 | TRPV1 (0.44) | TRPV1CNR2CNR1PKMCYP1A2 | |
| SCHEMBL19302724 | 0.75 | TRPV1 (0.49) | TRPV1CNR2CNR1PKMATM | |
| SCHEMBL20711268 | 0.73 | TRPV1 (0.50) | TRPV1CNR2CNR1TOP2A | |
| SCHEMBL20711262 | 0.72 | TRPV1 (0.47) | TRPV1CNR2CNR1PKMATM | |
| SCHEMBL7514634 | 0.72 | KMT2A (0.43) | PKMATMHSD17B10MEN1KMT2A | |
| SCHEMBL3453024 | 0.72 | POLB (0.39) | PKMATMHSD17B10CYP1A2TP53 | |
| SCHEMBL14417089 | 0.71 | TRPV1 (0.41) | TRPV1CNR2CNR1CYP1A2USP2 | |
| SCHEMBL4403741 | 0.70 | TRPV1 (0.48) | TRPV1CNR2CNR1PKMATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010735-B1 | MAYTANSINOIDS, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Chemical Industries, Ltd. (JP) | 1983-03-23 | — | — | EP | disclosed |
| US-4248870-A | MICROBIOCIDES, ANTITUMOR AGENTS, AND ANTIMITOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-02-03 | — | — | US | disclosed |
| EP-0010735-A1 | Maytansinoids, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-05-14 | — | — | EP | disclosed |