Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 7/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.73 |
| ▸ | SHBG | P04278 | 4/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.73 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.73 |
| ▸ | THPO | P40225 | 1/20 | 0.73 |
| ▸ | MTOR | P42345 | 1/20 | 0.73 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211930 | 1.00 | NR3C2 (0.73) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL11210479 | 0.91 | NR3C2 (0.71) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL11210476 | 0.91 | NR3C2 (0.71) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL3232371 | 0.90 | NR3C2 (0.80) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL15763286 | 0.90 | NR3C2 (0.80) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL142427 | 0.90 | NR3C2 (0.80) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL19327108 | 0.90 | NR3C2 (0.80) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL21231249 | 0.87 | HIF1A (0.76) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| SCHEMBL4714951 | 0.86 | SMN1; SMN2 (0.70) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 | |
| Corticosterone SCHEMBL5669349 | 0.85 | SMN1; SMN2 (1.00) | NR3C2SMN1; SMN2HIF1ASHBGSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047016-B1 | PROGESTERONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-14 | — | — | EP | claimed |
| US-4293548-A | DIURETICS, ALDOSTERONE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1981-10-06 | — | — | US | claimed |
| US-4293548-A | DIURETICS, ALDOSTERONE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1981-10-06 | — | — | US | disclosed |