Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoldopam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 17/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 8/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.97 |
| ▸ | THPO | P40225 | 2/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenoldopam SCHEMBL1319766 | 1.00 | KDM4E (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL1815791 | 0.99 | DRD1 (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL13287212 | 0.99 | DRD1 (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL34250 | 0.99 | DRD1 (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL9157427 | 0.99 | DRD1 (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL41214 | 0.99 | DRD1 (1.00) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL9157381 | 0.97 | DRD1 (0.97) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL29424282 | 0.97 | DRD1 (0.97) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL16241872 | 0.97 | DRD1 (0.97) | KDM4ERECQLBLMPOLBPMP22 | |
| Fenoldopam SCHEMBL3136078 | 0.93 | GFER (0.91) | KDM4ERECQLBLMPOLBPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087319-A1 | R- and S-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine | SMITHKLINE BECKMAN CORPORATION (US) | 1983-08-31 | — | — | EP | disclosed |