Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HAAO | P46952 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646160 | 0.86 | TDP1 (0.52) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL1919502 | 0.84 | TDP1 (0.50) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL2425023 | 0.82 | MAPT (0.68) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL2059405 | 0.82 | TDP1 (0.53) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL17371291 | 0.82 | TDP1 (0.68) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL30466426 | 0.82 | MAPT (0.68) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL979782 | 0.81 | HSD17B10 (0.51) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL2081501 | 0.81 | TDP1 (0.47) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL2429962 | 0.81 | TDP1 (0.47) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL5832803 | 0.81 | TDP1 (0.47) | TDP1MAPTALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093488-A2 | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-11-09 | — | — | EP | disclosed |