Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 20/20 | 0.67 |
| ▸ | HRH1 | P35367 | 7/20 | 0.67 |
| ▸ | SSTR1 | P30872 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121817 | 0.90 | SSTR5 (0.70) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121344 | 0.89 | SSTR5 (0.70) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121733 | 0.88 | SSTR5 (0.70) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121527 | 0.87 | SSTR5 (0.73) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121445 | 0.87 | SSTR5 (0.67) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121525 | 0.87 | SSTR5 (0.69) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121675 | 0.87 | SSTR5 (0.65) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121289 | 0.87 | SSTR5 (0.80) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL1121440 | 0.86 | SSTR5 (0.71) | SSTR5HRH1SSTR1KCNH2HTR2B | |
| SCHEMBL4943961 | 0.86 | SSTR5 (0.75) | SSTR5HRH1SSTR1KCNH2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-B1 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-02-09 | — | — | EP | claimed |