Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL11217167 | 0.99 | ACE (0.60) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL11298944 | 0.84 | ACE (0.58) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL11219110 | 0.82 | ACE (0.55) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL6436563 | 0.81 | ACE (0.65) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL6436560 | 0.81 | ACE (0.65) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL6438293 | 0.81 | ACE (0.65) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL6438290 | 0.81 | ACE (0.65) | ACELMNALTA4HSMN1; SMN2ACE2 | |
| SCHEMBL11219350 | 0.81 | ACE (0.49) | ACELMNA | |
| SCHEMBL10589628 | 0.80 | ACE (0.62) | ACELMNASMN1; SMN2 | |
| SCHEMBL11196039 | 0.80 | ACE (0.53) | ACELMNALTA4HSMN1; SMN2ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316896-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0009183-B1 | PHOSPHORYL AMINOACID DERIVATIVES AND COMPOSITION FOR TREATING HYPERTENSION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0009183-A1 | Phosphoryl aminoacid derivatives and composition for treating hypertension containing the same | MERCK & CO. INC. (US) | 1980-04-02 | — | — | EP | disclosed |