SCHEMBL11220533

SCHEMBL11220533

CC(=O)C(C(=O)O)C(Cl)(Cl)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.45
CYP2D6 P10635 2/20 0.43
MAPT P10636 2/20 0.38
KMT2A Q03164 1/20 0.38
TSHR P16473 1/20 0.38
KCNN4 O15554 1/20 0.37
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
ATM Q13315 1/20 0.37
KIF11 P52732 8/20 0.37
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2570877 0.78 CYP1A2 (0.44) CYP1A2CYP2D6MAPTKMT2AKCNN4
SCHEMBL28342294 0.74 CYP1A2 (0.50) CYP1A2CYP2D6MAPTKMT2ATSHR
SCHEMBL6363313 0.71 HDAC3 (0.50) CYP1A2CYP2D6MAPTKMT2AKCNN4
SCHEMBL7288198 0.71 CYP1A2 (0.48) CYP1A2CYP2D6MAPTKMT2AKCNN4
SCHEMBL28014001 0.71 CYP2D6 (0.44) CYP1A2CYP2D6MAPTKMT2ATSHR
Acetic Acid SCHEMBL28073831 0.70 TSHR (0.70) CYP1A2CYP2D6MAPTKMT2ATSHR
SCHEMBL10512060 0.69 TP53 (0.33) TSHRALDH1A1LMNA
SCHEMBL11715049 0.69 CYP1A2 (0.54) CYP1A2CYP2D6MAPTKMT2ATSHR
SCHEMBL9286120 0.69 CYP1A2 (0.45) CYP1A2CYP2D6MAPTKMT2AKCNN4
Chlorotriphenylmethane SCHEMBL11023533 0.69 CYP1A2 (0.54) CYP1A2CYP2D6MAPTKMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57018668-A None JP disclosed
JP-S5718668-A PREPARATION OF 4-BENZOYL-5-HYDROXYPYRAZOLE COMPOUND ISHIHARA SANGYO KAISHA LTD 1982-01-30 JP disclosed