Biphenyl

Biphenyl

SCHEMBL11221029

ClCc1ccccc1Cl.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.52
IDO1 P14902 3/20 0.50
PNMT P11086 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.47
CYP2A6 P11509 1/20 0.46
HIF1A Q16665 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
RAB9A P51151 1/20 0.44
ATM Q13315 1/20 0.44
CYP1A2 P05177 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
AOC3 Q16853 1/20 0.44
KCNH2 Q12809 1/20 0.44
ALDH1A1 P00352 2/20 0.43
HTR3E A5X5Y0 1/20 0.42
HTR3B O95264 1/20 0.42
HTR3A P46098 1/20 0.42
HTR3D Q70Z44 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL126469 0.90
SCHEMBL2520376 0.87 IDO1 (0.56) TAAR1IDO1PNMTSMN1; SMN2RAB9A
Hydrochloric Acid SCHEMBL29120628 0.87 IDO1 (0.56) TAAR1IDO1PNMTSMN1; SMN2RAB9A
SCHEMBL5345971 0.87 IDO1 (0.56) TAAR1IDO1PNMTSMN1; SMN2RAB9A
Ammonia Solution, Strong SCHEMBL21633813 0.87 IDO1 (0.56) TAAR1IDO1PNMTSMN1; SMN2RAB9A
Cyanide SCHEMBL28154275 0.83 IDO1 (0.52) TAAR1IDO1PNMTSMN1; SMN2RAB9A
SCHEMBL27739733 0.80 ESR2 (0.48) TAAR1SMN1; SMN2CYP2A6HIF1ACYP1A2
SCHEMBL6308178 0.80 ESR2 (0.53) TAAR1SMN1; SMN2CYP2A6CYP1A2ALDH1A1
SCHEMBL6740216 0.76 TAAR1 (0.71) TAAR1IDO1PNMTSLC6A2SLC6A4
Biphenyl SCHEMBL27751393 0.76 TSHR (0.71) TAAR1SMN1; SMN2CYP2A6L3MBTL1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57120571-A None JP disclosed
CN-104619717-A Synthesis of beta-turn peptidomimetic cyclic compounds MIMETOGEN PHARMACEUTICALS INC 2015-05-13 CN disclosed
CN-102225966-B Method for solid phase peptide synthesis LONZA AG 2012-12-26 CN disclosed
CN-102225966-A Method for solid phase peptide synthesis LONZA AG 2011-10-26 CN disclosed
CN-101094867-B Method for solid phase peptide synthesis LONZA AG 2011-08-24 CN disclosed
CN-101094867-A Method for solid phase peptide synthesis LONZA AG (CH) 2007-12-26 CN disclosed
JP-S57120571-A PREPARATION OF BISPHENYL 2- CHLOROPHENYLIMIDAZOYLMETHANE KOTOBUKI SEIYAKU KK 1982-07-27 JP disclosed