SCHEMBL112229

SCHEMBL112229

Cc1cc2ccccc2cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 1.00
CYP2A6 P11509 2/20 1.00
PDPK1 O15530 1/20 0.54
NPC1 O15118 2/20 0.46
RAB9A P51151 1/20 0.46
HTR3A P46098 1/20 0.44
PLAU P00749 1/20 0.44
TDP1 Q9NUW8 1/20 0.42
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPT P10636 1/20 0.39
PSMD14 O00487 1/20 0.39
COPS5 Q92905 1/20 0.39
UHRF1 Q96T88 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29561259 1.00 CYP1A2 (1.00) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL17532719 0.91 CYP1A2 (0.83) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL6066320 0.82 CYP1A2 (0.67) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL11646412 0.82 CYP1A2 (0.67) CYP1A2CYP2A6PDPK1NPC1RAB9A
SCHEMBL18266963 0.81 CYP1A2 (0.67) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL18266965 0.78 CYP1A2 (0.64) CYP1A2CYP2A6CCR1CCR5CCR8
SCHEMBL21547722 0.78 MAPT (0.69) CYP1A2CYP2A6HTR3AMAPT
SCHEMBL16905443 0.78 CYP1A2 (0.62) CYP1A2CYP2A6NPC1RAB9ATDP1
SCHEMBL8404528 0.76 CYP1A2 (0.61) CYP1A2CYP2A6TDP1CCR1CCR5
SCHEMBL29404737 0.76 CYP1A2 (0.61) CYP1A2CYP2A6TDP1CCR1CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2160 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118847244-A Synthesis method of nitrogen-containing heterocyclic sulfonyl chloride intermediate 北京六合宁远医药科技股份有限公司 2024-10-29 CN claimed
CN-118271331-A Gelsemin derivatives, synthesis method and application thereof in inhibiting tumor cell proliferation 赣江中药创新中心 2024-07-02 CN claimed
WO-2024017178-A1 SUBSTITUTED HYDANTOIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS AVITAR BIOSCIENCES, INC. (CN) 2024-01-25 WO claimed
CN-113072496-A Preparation method of isoquinoline-1-formamide compound 湖北工业大学 2021-07-06 CN claimed
CN-110818628-B Preparation method of nitrogen-containing aromatic dicarboxylic acid 常熟理工学院 2020-11-06 CN claimed
CN-110818628-A Preparation method of nitrogen-containing aromatic dicarboxylic acid 常熟理工学院 2020-02-21 CN claimed
EP-3542801-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES Boehringer Ingelheim International GmbH (DE) 2019-09-25 EP claimed
CN-105340100-B Organic electroluminescent device heterocyclic compound and application thereof 东曹株式会社 2018-01-30 CN claimed
US-20160136180-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES BOEHRINGER INGELHEIM INT (DE) 2016-05-19 US claimed
US-20110112069-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-12 US claimed
EP-1104417-A1 IMPROVED OMEPRAZOLE PROCESS AND COMPOSITIONS THEREOF Merck & Co., Inc. (US) 2001-06-06 EP claimed
US-6166213-A Omeprazole process and compositions thereof MERCK & CO., INC. (US) 2000-12-26 US claimed
WO-2000009497-A1 IMPROVED OMEPRAZOLE PROCESS AND COMPOSITIONS THEREOF MERCK & CO., INC. (US) 2000-02-24 WO claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
WO-1998033786-A9 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS 1998-12-30 WO claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed
US-4086229-A Dinitrosyldihalo complexes of molybdenum or tungsten PHILLIPS PETROLEUM COMPANY (US) 1978-04-25 US claimed
US-4061638-A Organocalciumpyridine-type polymerization initiators PHILLIPS PETROLEUM COMPANY (US) 1977-12-06 US claimed
US-3997708-A ADDITION PHILLIPS PETROLEUM COMPANY (US) 1976-12-14 US claimed
US-3975161-A QUINOLINES LACHEMA, NARODNI PODNIK (CS) 1976-08-17 US claimed