⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471736 | 0.69 | — | — | |
| SCHEMBL17399189 | 0.67 | — | — | |
| SCHEMBL11817477 | 0.65 | — | — | |
| SCHEMBL11813372 | 0.64 | — | — | |
| SCHEMBL18028206 | 0.64 | — | — | |
| SCHEMBL11196499 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL28937431 | 0.62 | — | — | |
| SCHEMBL15120736 | 0.61 | — | — | |
| SCHEMBL16215461 | 0.61 | — | — | |
| SCHEMBL10701107 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020116688-A1 | ANTICANCER SUPPLEMENT COMPRISING NC886 AND/OR PKR INHIBITOR, AND METHOD FOR PROVIDING INFORMATION OF DRUG FOR CANCER TREATMENT | 국립암센터 | 2020-06-11 | — | — | WO | claimed |
| CN-102341498-B | Natural antisense transcripton by suppressing VEGF (VEGF) treats the related diseases of VEGF | 库尔纳公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-107338251-A | It is diseases related that natural antisense transcript by suppressing tumor suppressor gene treats tumor suppressor gene | 库尔纳公司 | 2017-11-10 | — | — | CN | disclosed |
| CN-106083854-B | A kind of hypoxemia activation AGT protein inhibitors and preparation method and application | 北京工业大学 | 2017-10-27 | — | — | CN | disclosed |
| CN-105367573-B | AGT protein inhibitors, its preparation method and application | 北京工业大学 | 2017-07-14 | — | — | CN | disclosed |
| CN-102361985-B | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the tumor suppressor gene | 库尔纳公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106146484-A | Quinazoline derivant is as RAF kinase modulator and their method and purposes | 埃姆比特生物科学公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083854-A | A kind of hypoxia activates AGT protein inhibitor and preparation method and application | 北京工业大学 | 2016-11-09 | — | — | CN | disclosed |
| CN-105837560-A | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | 埃姆比特生物科学公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-105792831-A | Methods for treating fibrotic cancer | 普罗麦迪奥股份有限公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-102026985-B | Quinazoline derivatives as RAF kinase modulators and methods and uses thereof | 埃姆比特生物科学公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-105601619-A | JAK kinase modulating compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2016-05-25 | — | — | CN | disclosed |
| CN-103110948-A | Antineoplastic combinations with mTOR inhibitor,herceptin, and/or HKI-272 | WYETH CORP | 2013-05-22 | — | — | CN | disclosed |
| CN-102470127-A | Biaryl compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2012-05-23 | — | — | CN | disclosed |
| CN-101932333-A | Anti-c35 antibody combination therapies and methods | VACCINEX INC | 2010-12-29 | — | — | CN | disclosed |
| CN-101835472-A | Methods of administering N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease | AMBIT BIOSCIENCES CORP | 2010-09-15 | — | — | CN | disclosed |
| CN-101300029-A | Antitumor combinations of mTOR inhibitors, herceptins and/or HKI-272 | WYETH CORP (US) | 2008-11-05 | — | — | CN | disclosed |
| CN-1407900-A | Method for treating or preventing cell, tissue, and organ damage using human bone marrow progenitor cell inhibitory factor-1 (MPIF-1) | HUMAN GENOME SCIENCES INC (US) | 2003-04-02 | — | — | CN | disclosed |
| EP-0064091-A1 | Production of hydrocarbylthioaldoxime in aqueous methanol solvent | ALLIED CORPORATION (US) | 1982-11-10 | — | — | EP | disclosed |
| US-4336085-A | MODIFYING THE DETONATION VELOCITY | WALKER FRANKLIN E | 1982-06-22 | — | — | US | disclosed |