Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | F13A1 | P00488 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | TGM1 | P22735 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25547613 | 0.84 | MEN1 (0.49) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL9218512 | 0.84 | MEN1 (0.59) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL9572627 | 0.82 | MEN1 (0.57) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL7311393 | 0.81 | MEN1 (0.59) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL2797469 | 0.81 | GRM5 (0.55) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL21551374 | 0.81 | MEN1 (0.56) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL1813588 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL2771533 | 0.79 | MEN1 (0.51) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL4514146 | 0.79 | TMEM97 (0.54) | MEN1KMT2ANPSR1CYP1A2CYP3A4 | |
| SCHEMBL4514149 | 0.79 | TMEM97 (0.54) | MEN1KMT2ANPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353901-A | HYPERTENSION, CONGESTIVE HEART FAILURE, ARRHYTHMIAMIGRAINE, VASOSPASTIC DISORDERS, ASTHMA | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |