Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23440004 | 0.64 | — | — | |
| SCHEMBL19142493 | 0.62 | — | — | |
| SCHEMBL26210468 | 0.60 | MEN1 (0.30) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL29542985 | 0.59 | CYP3A4 (0.33) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL7679422 | 0.56 | CYP3A4 (0.38) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL19252986 | 0.55 | — | — | |
| SCHEMBL28334572 | 0.55 | — | — | |
| SCHEMBL11916077 | 0.54 | CYP3A4 (0.38) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL18649616 | 0.54 | CYP17A1 (0.35) | MEN1CYP1A2CYP3A4CYP2D6KMT2A | |
| SCHEMBL31737441 | 0.54 | CYP2D6 (0.64) | MEN1CYP1A2CYP3A4CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000383-B1 | PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-13 | — | — | EP | disclosed |
| EP-0000382-B1 | PYRIMIDO (4,5-C)PYRIDAZINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-06 | — | — | EP | disclosed |