Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230064 | 1.00 | MAPT (0.37) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL10783521 | 0.77 | GSK3B (0.61) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL5048603 | 0.77 | GSK3B (0.61) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL616019 | 0.72 | — | — | |
| SCHEMBL3767165 | 0.69 | MAPT (0.53) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL33554 | 0.69 | — | — | |
| SCHEMBL29398195 | 0.69 | — | — | |
| SCHEMBL29375766 | 0.69 | MAPT (0.53) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL29418986 | 0.69 | MAPT (0.53) | MAPTGAAKDM4EMEN1ALDH1A1 | |
| SCHEMBL27566643 | 0.69 | MAPT (0.53) | MAPTGAAKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4332810-A | N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics | MERCK & CO., INC. (US) | 1982-06-01 | — | — | US | disclosed |