Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11232233 | 0.84 | PDE3B (0.66) | PDE3BPDE3AAURKBINCENPPDE4A | |
| SCHEMBL11229235 | 0.83 | PDE3B (0.47) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11232058 | 0.82 | PDE3B (0.66) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11231253 | 0.82 | CDC7 (0.48) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11230175 | 0.80 | PDE3A (0.74) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11246018 | 0.80 | PDE3B (0.44) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11228691 | 0.80 | PDE3B (0.59) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11235965 | 0.79 | PDE3B (0.43) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11231275 | 0.79 | PDE3B (0.41) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11229942 | 0.78 | PDE3B (0.58) | PDE3BPDE3AAURKBINCENPGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4339584-A | Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones via N-hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide by reaction with polyphosphoric acid | STERLING DRUG INC. (US) | 1982-07-13 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |
| US-4305948-A | N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |