Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248815 | 1.00 | HTR2C (0.51) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11248801 | 1.00 | HTR2C (0.51) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11230923 | 1.00 | HTR2C (0.51) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11230951 | 1.00 | HTR2C (0.51) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11239669 | 0.87 | SLC6A4 (0.47) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11239674 | 0.87 | SLC6A4 (0.47) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11239671 | 0.87 | SLC6A4 (0.47) | HTR2CHTR2BSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19023240 | 0.82 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19023239 | 0.82 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19050113 | 0.82 | HRH1 (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |