Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.57 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236700 | 1.00 | KCNH2 (0.66) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL11233919 | 1.00 | KCNH2 (0.66) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| Hydrochloric Acid SCHEMBL11236309 | 0.98 | KCNH2 (0.64) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL11238993 | 0.98 | KCNH2 (0.63) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL3122783 | 0.97 | CHRM2 (0.65) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL3116995 | 0.97 | CHRM2 (0.65) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL3124265 | 0.97 | CHRM2 (0.65) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| Hydrochloric Acid SCHEMBL11229997 | 0.97 | KCNH2 (0.62) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| Hydrochloric Acid SCHEMBL11139285 | 0.93 | CHRM2 (0.63) | KCNH2CHRM2S1PR1S1PR3S1PR2 | |
| SCHEMBL3118575 | 0.91 | CHRM2 (0.59) | KCNH2CHRM2S1PR1S1PR3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336269-A | ANTIARRHYTHMIA | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4277501-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |