Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 6/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744912 | 0.90 | PDE2A (0.46) | PDE2APDE5APDE3BPDE3AKDM4E | |
| Hydrochloric Acid SCHEMBL10745716 | 0.89 | PDE2A (0.45) | PDE2APDE5APDE3BPDE3AKDM4E | |
| Hydrochloric Acid SCHEMBL11271594 | 0.88 | PDE5A (0.43) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL10746559 | 0.88 | PDE2A (0.44) | PDE2APDE5APDE3BPDE3AKDM4E | |
| Hydrochloric Acid SCHEMBL10746408 | 0.87 | PDE2A (0.43) | PDE2APDE5APDE3BPDE3AKDM4E | |
| Hydrochloric Acid SCHEMBL10748007 | 0.87 | MAPT (0.45) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL10748016 | 0.84 | PDE2A (0.53) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL11010061 | 0.84 | PDE2A (0.41) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL10745432 | 0.84 | CYP17A1 (0.61) | CYP17A1ENPP1 | |
| SCHEMBL10748642 | 0.84 | PDE2A (0.44) | PDE2APDE5APDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024290-B1 | 8-PHENYL PURINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-12-22 | — | — | EP | disclosed |
| US-4299834-A | INOTROPIC ACTIVITY | BOEHRINGER INGELHEIM GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-11-10 | — | — | US | disclosed |
| EP-0024290-A1 | 8-Phenyl purines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |