Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | DDO | Q99489 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29603529 | 1.00 | HCAR2 (1.00) | HCAR2POLBHTTALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL30444355 | 0.98 | HCAR2 (0.96) | HCAR2POLBHTTALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL9407495 | 0.98 | HCAR2 (0.96) | HCAR2POLBHTTALOX15KDM4E | |
| SCHEMBL10500665 | 0.98 | HCAR2 (0.96) | HCAR2POLBHTTALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL6525205 | 0.98 | HCAR2 (0.96) | HCAR2POLBHTTALOX15KDM4E | |
| SCHEMBL10461109 | 0.98 | HCAR2 (0.96) | HCAR2POLBHTTALOX15KDM4E | |
| Ethane SCHEMBL28837432 | 0.96 | HCAR2 (0.92) | HCAR2POLBHTTALOX15KDM4E | |
| Formaldehyde SCHEMBL27682220 | 0.96 | HCAR2 (0.92) | HCAR2POLBHTTALOX15KDM4E | |
| Nitrous Acid SCHEMBL27664646 | 0.92 | HCAR2 (0.85) | HCAR2POLBHTTALOX15KDM4E | |
| Methylene Chloride SCHEMBL28327546 | 0.92 | HCAR2 (0.85) | HCAR2POLBHTTALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2419 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118459395-A | Synthesis method of 5- (tert-butoxycarbonylamino) piperidine-3-carboxylic acid methyl ester | 南通大学 | 2024-08-09 | — | — | CN | claimed |
| CN-116987064-B | Preparation method and application of pyrimidine bisnicotinamide derivative | 宁夏佰斯特医药化工有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-114671861-B | Wogonin derivative and preparation method and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | claimed |
| CN-114716434-B | Nicergoline bulk drug and synthesis process thereof | 海南久常制药有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-116987064-A | Preparation method and application of pyrimidine bisnicotinamide derivative | 宁夏佰斯特医药化工有限公司 | 2023-11-03 | — | — | CN | claimed |
| CN-114573562-B | Niacin-containing triazole compound and preparation method and application thereof | 西安交通大学 | 2023-07-07 | — | — | CN | claimed |
| CN-111116580-B | Improved preparation method of nicergoline | 上海应用技术大学 | 2022-08-23 | — | — | CN | claimed |
| EP-3541402-B1 | C3A RECEPTOR AGONISTS FOR USE AGAINST ISCHEMIC BRAIN INJURY | PEKNA MARCELA (SE) | 2022-07-20 | — | — | EP | claimed |
| CN-108546225-B | Process for producing nitrile and corresponding amine | 中国石化扬子石油化工有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-114716434-A | Nicergoline raw material medicine and synthesis process thereof | 海南久常制药有限公司 | 2022-07-08 | — | — | CN | claimed |
| WO-1998033786-A9 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | — | 1998-12-30 | — | — | WO | claimed |
| WO-1998033786-A1 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-08-06 | — | — | WO | claimed |
| EP-0251732-B1 | PROCESS FOR THE PREPARATION OF 2-HALOGENATED ERGOLINE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1993-04-28 | — | — | EP | claimed |
| CN-1015365-B | PROCESS FOR THE PREPARATION OF 2-HALONICERGOLINE DERIVATIVES AND THEIR ACID ADDITION SALTS AND NEW 2-HALONICERGOLINES | RICHTER GEDEON VEGYESZET (HU) | 1992-02-05 | — | — | CN | claimed |
| US-4980475-A | Process for the preparation of N-10 alpha-methoxyl-lumilysergol and esters, thereof, and intermediates for their preparation | I D B HOLDING S.P.A. (IT) | 1990-12-25 | — | — | US | claimed |
| EP-0156645-B1 | PROCESS FOR THE PREPARATION OF N1-METHYL-10ALPHA-METHOXYLUMILYSERGOL AND ESTERS THEREOF, AND INTERMEDIATES FOR THEIR PREPARATION | INVERNI DELLA BEFFA S.P.A. (IT) | 1989-11-02 | — | — | EP | claimed |
| EP-0251732-A2 | Process for the preparation of 2-halogenated ergoline derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-01-07 | — | — | EP | claimed |
| CN-86104086-A | The preparation method of 2-halogen nicergoline derivatives and its acid salt and new 2-halogen Varson class | — | 1986-12-17 | — | — | CN | claimed |
| EP-0156645-A2 | Process for the preparation of N1-methyl-10alpha-methoxylumilysergol and esters thereof, and intermediates for their preparation | INVERNI DELLA BEFFA S.P.A. (IT) | 1985-10-02 | — | — | EP | claimed |
| US-4232157-A | Process for preparing lysergol derivatives | ISTITUTO CHEMIOTERAPICO DI LODI SPA, A CORP OF ITALY (IT) | 1980-11-04 | — | — | US | claimed |