Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | KDM6A | O15550 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211531 | 0.79 | CRBN (0.38) | CRBNKDM4EPIK3CDPIK3CAPIK3CB | |
| SCHEMBL100263 | 0.70 | CRBN (0.44) | CRBNKDM4EPIK3CDPIK3CAPIK3CB | |
| SCHEMBL10569040 | 0.70 | MAPK1 (0.44) | CRBNKDM4ECYP2C9CYP2C19 | |
| SCHEMBL10569045 | 0.70 | MAPK1 (0.44) | CRBNKDM4ECYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7524493 | 0.69 | CRBN (0.43) | CRBNKDM4EPIK3CDPIK3CAPIK3CB | |
| Water SCHEMBL6505685 | 0.69 | CRBN (0.43) | CRBNKDM4EPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15280674 | 0.67 | KDM4E (0.41) | CRBNKDM4EPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2272045 | 0.62 | — | — | |
| SCHEMBL7267469 | 0.62 | CRBN (0.37) | CRBNKDM4EKDM6AKDM4ACYP2C9 | |
| SCHEMBL14369885 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000383-B1 | PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-13 | — | — | EP | disclosed |