Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BCL9 | O00512 | 2/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239657 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11229809 | 0.96 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11229816 | 0.96 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11238711 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11231965 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11231957 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11235679 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11238706 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11235673 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL11245160 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |