Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 12/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242032 | 0.89 | PDE4B (0.51) | PDE3BPDE3APDE4BALDH1A1THRB | |
| SCHEMBL11242218 | 0.85 | PDE4B (0.48) | PDE3BPDE3APDE4BALDH1A1THRB | |
| SCHEMBL11240512 | 0.83 | PDE4B (0.52) | PDE4BALDH1A1THRBMEN1KMT2A | |
| SCHEMBL11247165 | 0.83 | PDE4B (0.43) | PDE3BPDE3APDE4BALDH1A1THRB | |
| SCHEMBL11238845 | 0.80 | KMT2A (0.45) | PDE4BALDH1A1MAPTTHRBMEN1 | |
| SCHEMBL11397250 | 0.78 | PDE3B (0.48) | PDE3BPDE3APDE4BALDH1A1THRB | |
| SCHEMBL11244877 | 0.76 | PDE4B (0.52) | PDE4BALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11236462 | 0.75 | PDE4A (0.50) | PDE3BPDE3APDE4BGAACYP19A1 | |
| Hydrochloric Acid SCHEMBL11238842 | 0.73 | PDE4A (0.49) | PDE3BPDE3APDE4BGAACYP19A1 | |
| SCHEMBL11163923 | 0.72 | KMT2A (0.52) | PDE3BPDE3APDE4BALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |