Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3361156 | 0.95 | TSHR (0.70) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL2687062 | 0.93 | TSHR (0.73) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL7994092 | 0.87 | TSHR (0.59) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL28207176 | 0.86 | TSHR (0.81) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL30604742 | 0.85 | TSHR (0.84) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL93462 | 0.85 | TSHR (0.84) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL28207751 | 0.85 | TSHR (0.79) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acetic Acid SCHEMBL11743292 | 0.84 | TSHR (0.83) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL1368610 | 0.84 | TSHR (0.67) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| Acrylic Acid SCHEMBL27896375 | 0.84 | TSHR (0.67) | TSHRALDH1A1TP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309484-A | CROSSLINKED HYDRATION PRODUCT OF COPOLYMER OF ETHYLENE AND GLYCIDYL ACRYLATE OR METHACRYLATE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-01-05 | — | — | US | disclosed |