Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.78 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11238448 | 1.00 | KCNH2 (0.78) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11229380 | 0.99 | KCNH2 (0.76) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11243846 | 0.99 | KCNH2 (0.76) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11229373 | 0.99 | KCNH2 (0.76) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11243849 | 0.99 | KCNH2 (0.76) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11234803 | 0.99 | KCNH2 (0.76) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11229293 | 0.97 | KCNH2 (0.74) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11229297 | 0.97 | KCNH2 (0.74) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11238473 | 0.97 | KCNH2 (0.74) | KCNH2THRATHRBHAO1ALDH1A1 | |
| Oxalic Acid SCHEMBL11238467 | 0.97 | KCNH2 (0.74) | KCNH2THRATHRBHAO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336269-A | ANTIARRHYTHMIA | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4277501-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |