SCHEMBL11243867

SCHEMBL11243867

O=C(O)c1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1C(=O)O

nearest known ligand 0.72

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.72
TTR P02766 1/20 0.72
PPOX P50336 1/20 0.72
KMT2A Q03164 1/20 0.72
TDP1 Q9NUW8 1/20 0.72
FFAR1 O14842 5/20 0.60
MRGPRX4 Q96LA9 7/20 0.54
PYGL P06737 2/20 0.51
PYGM P11217 1/20 0.51
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
HPGD P15428 2/20 0.48
HSD17B10 Q99714 2/20 0.48
USP2 O75604 1/20 0.48
CYP2C19 P33261 1/20 0.48
SORT1 Q99523 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6290662 0.92 MEN1 (0.72) MEN1TTRPPOXKMT2ATDP1
SCHEMBL10661473 0.90 MEN1 (0.69) MEN1TTRPPOXKMT2ATDP1
SCHEMBL8378139 0.90 MEN1 (0.69) MEN1TTRPPOXKMT2ATDP1
SCHEMBL11116540 0.90 MEN1 (0.69) MEN1TTRPPOXKMT2ATDP1
SCHEMBL9506722 0.90 MEN1 (0.66) MEN1TTRPPOXKMT2ATDP1
SCHEMBL10665096 0.88 MEN1 (0.68) MEN1TTRPPOXKMT2ATDP1
SCHEMBL9796493 0.88 MEN1 (0.68) MEN1TTRPPOXKMT2ATDP1
SCHEMBL10656214 0.88 MEN1 (0.68) MEN1TTRPPOXKMT2ATDP1
SCHEMBL10665077 0.86 MEN1 (0.65) MEN1TTRPPOXKMT2ATDP1
SCHEMBL11245338 0.85 MEN1 (0.64) MEN1TTRPPOXKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4334915-A Phenoxyphthalates and herbicide containing the same NIHON NOHYAKU CO. LTD. (JP) 1982-06-15 US claimed
US-4334915-A Phenoxyphthalates and herbicide containing the same NIHON NOHYAKU CO. LTD. (JP) 1982-06-15 US disclosed