Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 19/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28759525 | 0.85 | NR1H2 (0.42) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27653887 | 0.83 | NR1H2 (0.49) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125578 | 0.83 | NR1H2 (0.65) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27653875 | 0.82 | NR1H2 (0.58) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27674072 | 0.82 | NR1H2 (0.43) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27653968 | 0.80 | NR1H2 (0.46) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27653850 | 0.80 | NR1H2 (0.53) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27673895 | 0.80 | NR1H2 (0.59) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27674035 | 0.80 | NR1H2 (0.49) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124878 | 0.79 | NR1H2 (0.41) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1914173-A | Quinolines useful in treating cardiovascular disease | WYETH CORP (US) | 2007-02-14 | — | — | CN | claimed |
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | disclosed |
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | disclosed |