Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.58 |
| ▸ | APP | P05067 | 4/20 | 0.58 |
| ▸ | ACP1 | P24666 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243968 | 0.91 | GBA1 (0.70) | GBA1APPACP1PDE5ACASP6 | |
| SCHEMBL15502283 | 0.89 | ACP1 (0.68) | GBA1APPACP1PDE5ACASP6 | |
| SCHEMBL11665848 | 0.87 | APP (0.63) | GBA1APPACP1PDE5ACASP6 | |
| SCHEMBL23723479 | 0.85 | KMT2A (0.70) | GBA1APPPDE5AMEN1KMT2A | |
| SCHEMBL4904310 | 0.83 | APP (0.70) | APPACP1PDE5ACASP6KDM4E | |
| SCHEMBL11245206 | 0.83 | APP (0.62) | GBA1APPACP1PDE5AMEN1 | |
| SCHEMBL11243280 | 0.83 | APP (0.62) | GBA1APPACP1PDE5AMEN1 | |
| SCHEMBL11254689 | 0.82 | MEN1 (0.59) | GBA1APPPDE5AMEN1KMT2A | |
| SCHEMBL8897898 | 0.80 | CYP1A2 (0.68) | APPPDE5AMEN1KMT2AKDM4E | |
| SCHEMBL11256778 | 0.79 | SMN1; SMN2 (0.75) | GBA1APPMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |