Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 19/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1125396 | 0.95 | NR1H2 (0.54) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1124749 | 0.92 | NR1H2 (0.54) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1124939 | 0.89 | NR1H2 (0.54) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125243 | 0.87 | NR1H2 (0.69) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125227 | 0.87 | NR1H2 (0.66) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125236 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125070 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125144 | 0.85 | NR1H2 (0.57) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1126178 | 0.84 | NR1H2 (0.61) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125391 | 0.83 | NR1H2 (0.66) | NR1H2NR1H3RXRAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | claimed |
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | disclosed |