Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | PPARD | Q03181 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 13/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124816 | 0.89 | NR1H2 (0.76) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125566 | 0.82 | NR1H2 (0.84) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125981 | 0.80 | NR1H2 (0.70) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125786 | 0.78 | NR1H2 (0.67) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1126467 | 0.77 | NR1H2 (0.60) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125913 | 0.76 | NR1H2 (0.75) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125273 | 0.76 | NR1H2 (0.90) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125409 | 0.76 | NR1H2 (0.74) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL17413684 | 0.76 | FFAR1 (0.80) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL14274514 | 0.75 | NR1H2 (0.80) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | claimed |