Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | ESR1 | P03372 | 12/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260213 | 1.00 | CYP19A1 (0.60) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11268234 | 1.00 | CYP19A1 (0.60) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11260199 | 1.00 | CYP19A1 (0.60) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11258760 | 1.00 | CYP19A1 (0.60) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11260845 | 0.89 | ESR1 (0.66) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11259670 | 0.83 | CYP19A1 (0.60) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL9414870 | 0.83 | CYP19A1 (0.54) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL30534786 | 0.82 | CYP19A1 (0.59) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL30534779 | 0.82 | ESR1 (0.64) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL9415318 | 0.81 | CYP2D6 (0.67) | CYP19A1CYP3A4ESR1MAPTADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019377-B1 | 1-HYDROCARBYLOXYPHENYL-1,2-DIPHENYLALKENE DERIVATIVES, THEIR MANUFACTURE AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-08-04 | — | — | EP | disclosed |
| US-4307111-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| EP-0019377-A1 | 1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives, their manufacture and a pharmaceutical composition containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-11-26 | — | — | EP | disclosed |