Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.73 |
| ▸ | NR1H3 | Q13133 | 19/20 | 0.73 |
| ▸ | RXRA | P19793 | 1/20 | 0.73 |
| ▸ | PPARG | P37231 | 2/20 | 0.72 |
| ▸ | PPARD | Q03181 | 1/20 | 0.72 |
| ▸ | PPARA | Q07869 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1125618 | 0.93 | NR1H2 (0.75) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125345 | 0.90 | NR1H2 (0.67) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125504 | 0.90 | NR1H2 (0.67) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125184 | 0.90 | NR1H2 (0.75) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125610 | 0.90 | NR1H2 (0.72) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125586 | 0.90 | NR1H2 (0.76) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125090 | 0.89 | NR1H2 (0.73) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1124889 | 0.89 | NR1H2 (0.76) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125425 | 0.89 | NR1H2 (0.80) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1126230 | 0.89 | NR1H2 (0.65) | NR1H2NR1H3RXRAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | claimed |
| US-7576215-B2 | Quinolines and pharmaceutical compositions thereof | WYETH (US) | 2009-08-18 | — | — | US | claimed |
| JP-2007516258-A | — | — | 2007-06-21 | — | — | JP | claimed |
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | claimed |
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | disclosed |