SCHEMBL11260591

SCHEMBL11260591

CN1CCCCC1CCCBr

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.58
ADRA2A P08913 2/20 0.45
DRD2 P14416 3/20 0.41
HTR2A P28223 3/20 0.41
HTR7 P34969 3/20 0.41
HTR6 P50406 3/20 0.41
CHRM1 P11229 1/20 0.39
ALDH1A1 P00352 1/20 0.39
S1PR1 P21453 1/20 0.38
S1PR3 Q99500 1/20 0.38
S1PR5 Q9H228 1/20 0.38
PIM1 P11309 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14861532 0.94 CYP1A2 (0.56) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL28365923 0.92 CYP1A2 (0.55) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL14861444 0.92 CYP1A2 (0.55) CYP1A2ADRA2ADRD2HTR2AHTR7
Bromide SCHEMBL31425229 0.89 CYP1A2 (0.51) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL1561038 0.88 CYP1A2 (0.62) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL2017584 0.87 CYP1A2 (0.67) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL15508580 0.82 CYP1A2 (0.60) CYP1A2ADRA2ADRD2HTR2AHTR7
SCHEMBL12715969 0.81
SCHEMBL19376421 0.81 CYP1A2 (0.57) CYP1A2ADRA2AALDH1A1S1PR1S1PR3
SCHEMBL4298771 0.80 CYP1A2 (0.58) CYP1A2ADRA2ACHRM1ALDH1A1S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4341906-A ANALGESICS PFIZER INC. (US) 1982-07-27 US disclosed
US-4310669-A TETRALONE PFIZER INC. (US) 1982-01-12 US disclosed
US-4310668-A Intermediates to 1,9-dihydroxyoctahydrophenanthrenes PFIZER INC. (US) 1982-01-12 US disclosed
US-4310529-A ANALGESICS PFIZER INC. (US) 1982-01-12 US disclosed
US-4270005-A ANALGESICS PFIZER INC. (US) 1981-05-26 US disclosed
US-4268523-A ANALGESICS PFIZER INC. (US) 1981-05-19 US disclosed
US-4268692-A ANALGESICS PFIZER INC. (US) 1981-05-19 US disclosed
US-4237133-A ANALGESICS PFIZER INC. (US) 1980-12-02 US disclosed
US-4188495-A 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor PFIZER INC. (US) 1980-02-12 US disclosed