Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 6/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237402 | 0.90 | PDE2A (0.67) | PDE2APDE5AMETAP2METAP1LMNA | |
| Hydrochloric Acid SCHEMBL11245060 | 0.90 | PDE2A (0.53) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11003447 | 0.86 | PDE2A (0.42) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11010662 | 0.86 | PDE5A (0.42) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11009231 | 0.86 | PDE5A (0.42) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11010695 | 0.86 | PDE5A (0.42) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11259754 | 0.86 | PDE2A (0.51) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL11234356 | 0.84 | PDE2A (0.49) | PDE2APDE5AMETAP2METAP1NPY5R | |
| SCHEMBL10686656 | 0.84 | PDE2A (0.53) | PDE2APDE5ALMNAMEN1KMT2A | |
| SCHEMBL10963633 | 0.83 | PDE5A (0.43) | PDE2APDE5AMETAP2METAP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024290-B1 | 8-PHENYL PURINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-12-22 | — | — | EP | disclosed |
| US-4299834-A | INOTROPIC ACTIVITY | BOEHRINGER INGELHEIM GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-11-10 | — | — | US | disclosed |
| EP-0024290-A1 | 8-Phenyl purines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |