Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 12/20 | 0.57 |
| ▸ | DRD2 | P14416 | 9/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | THPO | P40225 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GMNN | O75496 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11254711 | 0.87 | DRD1 (0.53) | DRD1DRD2ALOX15HSD17B10MTOR | |
| SCHEMBL11271845 | 0.85 | DRD1 (0.76) | DRD1DRD2ALOX15HSD17B10MTOR | |
| Bromide SCHEMBL11157745 | 0.84 | DRD1 (0.77) | DRD1DRD2ALOX15HSD17B10MTOR | |
| Bromide SCHEMBL11544890 | 0.83 | DRD1 (0.67) | DRD1DRD2ALOX15HSD17B10MTOR | |
| SCHEMBL11478102 | 0.82 | DRD1 (0.58) | DRD1DRD2ALOX15HSD17B10MTOR | |
| SCHEMBL7318885 | 0.79 | DRD1 (0.74) | DRD1DRD2ALOX15HSD17B10MTOR | |
| SCHEMBL11544635 | 0.79 | DRD1 (0.54) | DRD1DRD2ALOX15HSD17B10MTOR | |
| Hydrochloric Acid SCHEMBL11259745 | 0.78 | DRD1 (0.39) | DRD1DRD2ALOX15HSD17B10MTOR | |
| Bromide SCHEMBL7321599 | 0.78 | DRD1 (0.75) | DRD1DRD2ALOX15HSD17B10MTOR | |
| Bromide SCHEMBL11528515 | 0.77 | DRD1 (0.71) | DRD1DRD2ALOX15HSD17B10MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002327-B1 | PHARMACOLOGICALLY ACTIVE 6-LOWER ALKYL-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, METHOD OF PREPARING THEM AND INTERMEDIATES | SMITHKLINE BECKMAN CORPORATION (US) | 1982-08-04 | — | — | EP | disclosed |
| US-4342686-A | Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| US-4265889-A | DOPAMINERGIC, HYPOTENSIVE | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0002327-A1 | Pharmacologically active 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, method of preparing them and intermediates | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-13 | — | — | EP | disclosed |