Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 18/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127084 | 0.93 | FGFR3 (0.64) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3316059 | 0.85 | FGFR3 (0.52) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1126501 | 0.83 | FGFR3 (0.68) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1126101 | 0.82 | FGFR3 (0.67) | FGFR3 | |
| SCHEMBL3317165 | 0.78 | FGFR3 (0.66) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| Amitrole SCHEMBL3317173 | 0.75 | FGFR3 (0.51) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3316051 | 0.75 | FGFR3 (0.51) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1126738 | 0.74 | FGFR3 (0.58) | FGFR3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1127004 | 0.72 | FGFR3 (0.73) | FGFR3 | |
| SCHEMBL1126278 | 0.72 | FGFR3 (0.70) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2011-02-16 | — | — | EP | claimed |
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | claimed |