Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126643 | 0.88 | TSHR (0.54) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1994935 | 0.88 | TSHR (0.54) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1127099 | 0.87 | TSHR (0.57) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1126702 | 0.85 | TSHR (0.53) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1126553 | 0.84 | TSHR (0.55) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1126564 | 0.84 | TSHR (0.58) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1994159 | 0.83 | TSHR (0.54) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL1127125 | 0.83 | HPGD (0.54) | TSHRSMN1; SMN2HPGDLMNAALDH1A1 | |
| SCHEMBL1993390 | 0.82 | TSHR (0.53) | TSHRMAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL16500353 | 0.81 | TSHR (0.53) | TSHRMAPTSMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-B1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| EP-2626361-A1 | Pyrrole antifungal agents | F2G Limited (GB) | 2013-08-14 | — | — | EP | disclosed |
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |