SCHEMBL11268638

SCHEMBL11268638

CC(C)(C(=O)O)C(=O)C(Br)Oc1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.50
CYP3A4 P08684 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2C19 P33261 2/20 0.50
CYP2D6 P10635 1/20 0.50
MAPT P10636 1/20 0.50
PPARG P37231 13/20 0.44
FABP2 P12104 1/20 0.44
SLC22A12 Q96S37 1/20 0.44
CYP2C9 P11712 2/20 0.43
ADORA3 P0DMS8 1/20 0.42
CHRM1 P11229 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
ADRA1A P35348 1/20 0.42
SLC6A3 Q01959 1/20 0.42
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11276687 0.86 PPARA (0.41) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL8496952 0.85 CYP3A4 (0.51) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11274755 0.85 PPARA (0.41) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11282053 0.84 CYP3A4 (0.42) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11277913 0.84 PPARA (0.40) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11276032 0.84 CYP3A4 (0.42) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11292911 0.83 PPARA (0.41) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11268073 0.82 PPARA (0.51) PPARACYP3A4MEN1KMT2ACYP1A2
SCHEMBL11275325 0.81 CYP3A4 (0.47) CYP3A4MEN1KMT2ACYP1A2CYP2C19
SCHEMBL11272661 0.81 PPARA (0.56) PPARACYP3A4MEN1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4331674-A Combating fungi with 4-phenoxy-4-(azolyl-1-yl)-butanoic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed