SCHEMBL11269836

SCHEMBL11269836

CCCC=C(c1ccccc1)c1ccc2nc(N)n(C3=NCCS3)c2c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 1/20 0.32
ACSS2 Q9NR19 1/20 0.31
POLB P06746 1/20 0.31
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11269832 1.00 PI4KB (0.32) PI4KBACSS2POLBSIGMAR1
SCHEMBL11263874 0.88 PI4KB (0.35) PI4KB
SCHEMBL11263866 0.88 PI4KB (0.35) PI4KB
SCHEMBL11147951 0.85 PI4KB (0.33) PI4KB
SCHEMBL11147950 0.85 PI4KB (0.33) PI4KB
Hydrochloric Acid SCHEMBL11161333 0.84 PI4KB (0.32) PI4KB
Hydrochloric Acid SCHEMBL11161335 0.84 PI4KB (0.32) PI4KB
SCHEMBL11156324 0.83 CLK4 (0.36) PI4KB
SCHEMBL11156325 0.83 CLK4 (0.36) PI4KB
SCHEMBL11150190 0.83 PI4KB (0.37) PI4KBACSS2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4150028-A Antiviral thiazolinyl benzimidazoles ELI LILLY AND COMPANY (US) 1979-04-17 US claimed
US-4338315-A RHINOVIRUSES ELI LILLY AND COMPANY (US) 1982-07-06 US disclosed
US-4293558-A Antiviral thiazolinyl benzimidazoles and derivatives ELI LILLY AND COMPANY (US) 1981-10-06 US disclosed
US-4216313-A Antiviral thiazinyl benzimidazoles ELI LILLY AND COMPANY (US) 1980-08-05 US disclosed
US-4150028-A Antiviral thiazolinyl benzimidazoles ELI LILLY AND COMPANY (US) 1979-04-17 US disclosed