⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448164 | 0.87 | — | — | |
| SCHEMBL168677 | 0.82 | — | — | |
| SCHEMBL27815530 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL29350580 | 0.80 | KDM4E (0.31) | — | |
| SCHEMBL29564458 | 0.80 | — | — | |
| Ethoxycarbonyl Group SCHEMBL27962731 | 0.79 | — | — | |
| Phosphoric Acid SCHEMBL30913886 | 0.72 | — | — | |
| Oxalic Acid SCHEMBL30288221 | 0.72 | — | — | |
| SCHEMBL1703445 | 0.71 | — | — | |
| Pyrimidine SCHEMBL29211317 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107903276-B | A kind of method of asymmetric synthesis of cephalotaxine skeleton E ring | 河北科技大学 | 2019-09-17 | — | — | CN | claimed |
| CN-107903276-A | A kind of method of asymmetric synthesis of cephalotaxine skeleton E rings | 河北科技大学 | 2018-04-13 | — | — | CN | claimed |
| CN-107849054-A | NOTCH path signal conduction depressant drug compounds | 伊莱利利公司 | 2018-03-27 | — | — | CN | claimed |
| CN-105143230-B | Tricyclic compound for suppressing CFTR passages | 诺华股份有限公司 | 2017-06-09 | — | — | CN | claimed |
| CN-104136438-B | Quinolyl pyrrolopyrimidyl fused ring compound or salt thereof | TAIHO PHARMACEUTICAL CO.,LTD. (JP) | 2016-04-06 | — | — | CN | claimed |
| CN-105143230-A | Tricyclic compounds for inhibiting the CFTR channel | NOVARTIS AG | 2015-12-09 | — | — | CN | claimed |
| CN-107903276-B | A kind of method of asymmetric synthesis of cephalotaxine skeleton E ring | 河北科技大学 | 2019-09-17 | — | — | CN | disclosed |
| CN-107903276-B | A kind of method of asymmetric synthesis of cephalotaxine skeleton E ring | 河北科技大学 | 2019-09-17 | — | — | CN | disclosed |
| CN-109689027-A | Triglycerides aural preparations and application thereof | 奥德纳米有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109111459-A | The ester derivant of cephalotaxine containing salicylic acid, manufacturing method and application thereof | 南华大学 | 2019-01-01 | — | — | CN | disclosed |
| CN-108391422-A | Pyrrolobenzodiazepine antibody-drug conjugates and methods of use | 豪夫迈·罗氏有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-107903276-A | A kind of method of asymmetric synthesis of cephalotaxine skeleton E rings | 河北科技大学 | 2018-04-13 | — | — | CN | disclosed |
| CN-107849054-A | NOTCH path signal conduction depressant drug compounds | 伊莱利利公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-1665780-A | Tricyclic steroid hormone nuclear receptor modulators | LILLY CO ELI (US) | 2005-09-07 | — | — | CN | disclosed |
| EP-0763036-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-0763037-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 2001-11-14 | — | — | EP | disclosed |
| EP-0763037-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 1997-03-19 | — | — | EP | disclosed |
| EP-0763036-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995032972-A1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 1995-12-07 | — | — | WO | disclosed |
| WO-1995032970-A1 | (a)-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 1995-12-07 | — | — | WO | disclosed |