Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 18/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL11273045 | 1.00 | CYP3A4 (0.65) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11272049 | 1.00 | CYP3A4 (0.65) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11272043 | 1.00 | CYP3A4 (0.65) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11285095 | 0.99 | CYP3A4 (0.66) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11285082 | 0.99 | CYP3A4 (0.66) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11271631 | 0.97 | CYP3A4 (0.67) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11271628 | 0.97 | CYP3A4 (0.67) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11264740 | 0.94 | CYP3A4 (0.69) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11264729 | 0.94 | CYP3A4 (0.69) | CYP3A4THRBKDM4ELMNACYP51A1 | |
| Nitric Acid SCHEMBL11273562 | 0.91 | CYP3A4 (0.71) | CYP3A4THRBKDM4ELMNACYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338327-A | PROTECTION OF PLANTS AGAINST FUGAL ATTACK | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-06 | — | — | US | disclosed |