Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | APP | P05067 | 6/20 | 0.64 |
| ▸ | SNCA | P37840 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
| ▸ | PTPRC | P08575 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | S100A4 | P26447 | 1/20 | 0.53 |
| ▸ | USP18 | Q9UMW8 | 2/20 | 0.50 |
| ▸ | UCHL5 | Q9Y5K5 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9287352 | 0.92 | MAPT (0.62) | MAPTAPPSNCASMN1; SMN2CASP3 | |
| SCHEMBL28647928 | 0.86 | MAPT (0.63) | MAPTAPPSNCASMN1; SMN2CASP3 | |
| SCHEMBL22625286 | 0.83 | LCK (0.66) | MAPTAPPSMN1; SMN2USP2LCK | |
| SCHEMBL28405567 | 0.82 | METAP1 (0.62) | MAPTSMN1; SMN2RAB9AMETAP1PTPRC | |
| SCHEMBL30396785 | 0.82 | METAP1 (0.62) | MAPTSMN1; SMN2RAB9AMETAP1PTPRC | |
| SCHEMBL7152082 | 0.80 | MAPT (0.57) | MAPTAPPSNCASMN1; SMN2CASP3 | |
| SCHEMBL27477775 | 0.79 | PTPRC (0.71) | MAPTSMN1; SMN2RAB9APTPRCBCHE | |
| SCHEMBL8484153 | 0.79 | APP (1.00) | MAPTAPPSNCASMN1; SMN2RAB9A | |
| SCHEMBL17175833 | 0.79 | MAPT (0.58) | MAPTAPPSNCASMN1; SMN2CASP3 | |
| SCHEMBL8484149 | 0.79 | APP (1.00) | MAPTAPPSNCASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326064-A | CORONARODILATING ACTIVITY | VIGANTE BRIGITA A | 1982-04-20 | — | — | US | disclosed |
| US-4252956-A | CORONARY ARTERY DILATORS | VIGANTE BRIGITA A | 1981-02-24 | — | — | US | disclosed |