Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275850 | 0.89 | KDM4E (0.40) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| SCHEMBL11271105 | 0.88 | KDM4E (0.42) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL11278822 | 0.88 | KDM4E (0.40) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| SCHEMBL11273594 | 0.79 | PSEN1 (0.42) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| SCHEMBL11283136 | 0.79 | KDM4E (0.39) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL11286341 | 0.78 | KDM4E (0.38) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| SCHEMBL6598625 | 0.69 | HRH3 (0.69) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| SCHEMBL11277174 | 0.69 | KDM4E (0.41) | KDM4EHRH3CHRNB2CHRNA4ESR1 | |
| SCHEMBL11370270 | 0.68 | KDM4E (0.45) | KDM4EMAPTHRH3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL11286157 | 0.68 | KDM4E (0.40) | KDM4EHRH3ESR1ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322370-A | Polycyclic compounds | BEECHAM GROUP LIMITED (GB) | 1982-03-30 | — | — | US | disclosed |