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SCHEMBL11277593

SCHEMBL11277593

N=C(N)Nc1ccc(C(=O)Oc2ccc(CCC(=O)OCC(=O)NC3CCCCC3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.48
▸ POLB P06746 2/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.46
▸ MAPT P10636 3/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ ATM Q13315 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11285570 1.00 KMT2A (0.48) KMT2APOLBMEN1ALDH1A1MAPT
SCHEMBL11270219 0.99 KMT2A (0.49) KMT2APOLBMEN1ALDH1A1MAPT
SCHEMBL11273714 0.91 SMN1; SMN2 (0.56) KMT2APOLBMEN1ALDH1A1SMN1; SMN2
SCHEMBL11272631 0.91 SMN1; SMN2 (0.56) KMT2APOLBMEN1ALDH1A1SMN1; SMN2
SCHEMBL11281075 0.91 SMN1; SMN2 (0.56) KMT2APOLBMEN1ALDH1A1SMN1; SMN2
SCHEMBL11271622 0.90 SMN1; SMN2 (0.54) KMT2APOLBMEN1ALDH1A1SMN1; SMN2
SCHEMBL11270445 0.89 KMT2A (0.58) KMT2APOLBMEN1ALDH1A1MAPT
SCHEMBL11278725 0.89 KMT2A (0.58) KMT2APOLBMEN1ALDH1A1MAPT
SCHEMBL11272830 0.89 KMT2A (0.58) KMT2APOLBMEN1ALDH1A1MAPT
SCHEMBL11278486 0.88 SMN1; SMN2 (0.52) KMT2APOLBMEN1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4310533-A INHIBITING PLASMIN AND-OR TRYSIN ACTIVITY ONO PHARMACEUTICAL CO., LTD. (JP) 1982-01-12 — — US disclosed