Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.58 |
| ▸ | HTR2C | P28335 | 7/20 | 0.58 |
| ▸ | HTR2B | P41595 | 7/20 | 0.58 |
| ▸ | DRD3 | P35462 | 6/20 | 0.58 |
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | DRD4 | P21917 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTR1D | P28221 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11289973 | 0.86 | HTR2A (0.47) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL7409188 | 0.86 | HTR2A (0.47) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL11377237 | 0.82 | HTR2A (0.57) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL3633445 | 0.80 | HTR2A (0.62) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL11364743 | 0.75 | HTR2A (0.67) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL11364744 | 0.75 | HTR2A (0.67) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL11288242 | 0.75 | HTR2A (0.67) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| SCHEMBL11364739 | 0.75 | HTR2A (0.67) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mianserin SCHEMBL23326358 | 0.74 | DRD3 (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mianserin SCHEMBL9122085 | 0.74 | DRD3 (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333935-A | Antianxiety compositions of 10-hydroxy 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-1,2a azepines and a method of use thereof | AKZONA INCORPORATED (US) | 1982-06-08 | — | — | US | disclosed |
| US-4284559-A | 10-Hydroxy-1,2,3,4,10,14b-hexahydrodibenzo-[c,f] pyrazino-1,2a-azepines | AKZONA INCORPORATED (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0009284-A1 | Novel tetracyclic compounds, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1980-04-02 | — | — | EP | disclosed |