Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.50 |
| ▸ | REN | P00797 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PEPD | P12955 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278002 | 1.00 | ACE (0.50) | ACERENKDM4EF2LMNA | |
| SCHEMBL11275762 | 0.90 | ACE (0.56) | ACERENKDM4EF2LMNA | |
| SCHEMBL11275765 | 0.90 | ACE (0.56) | ACERENKDM4EF2LMNA | |
| SCHEMBL11264783 | 0.79 | ACE (0.48) | ACERENKDM4EF2LMNA | |
| SCHEMBL11264792 | 0.79 | ACE (0.48) | ACERENKDM4EF2LMNA | |
| SCHEMBL11282262 | 0.79 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL11282259 | 0.79 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL10508293 | 0.79 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL7378528 | 0.79 | ACE (0.62) | ACERENKDM4EF2LMNA | |
| SCHEMBL10954711 | 0.79 | ACE (0.62) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4331806-A | Dithioacyldihydropyrazole carboxylic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4288368-A | Dithioacylproline derivatives | E. R. SQUIBB & SONS, INC. (US) | 1981-09-08 | — | — | US | disclosed |