Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720121 | 0.85 | PARP1 (0.53) | PARP1CYP1A2KDM4E | |
| SCHEMBL1720598 | 0.83 | PARP1 (0.49) | PARP1KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL1719750 | 0.81 | PARP1 (0.56) | PARP1KDM4E | |
| SCHEMBL4068289 | 0.80 | PARP1 (0.55) | PARP1KDM4E | |
| SCHEMBL1720503 | 0.80 | PARP1 (0.55) | PARP1 | |
| SCHEMBL1720862 | 0.80 | PARP1 (0.55) | PARP1 | |
| SCHEMBL1719969 | 0.80 | PARP1 (0.53) | PARP1CYP1A2KDM4EHSD17B10CYP2C9 | |
| Hydrochloric Acid SCHEMBL1719747 | 0.79 | PARP1 (0.54) | PARP1KDM4E | |
| SCHEMBL1720304 | 0.79 | PARP1 (0.53) | PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1719833 | 0.78 | PARP1 (0.49) | PARP1KDM4EHSD17B10SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4113731-A | PHOTOGRAPHIC EMULSION STABILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1978-09-12 | — | — | US | claimed |
| EP-0005745-B1 | PYRAZOLO (3,4-C) AND THIAZOLO (5,4-C) ISOQUINOLINES, METHODS FOR PREPARING THEM, THESE COMPOUNDS FOR USE AS ANTIINFLAMMATORY, CNS-DEPRESSANT AND ANTI-ANXIETY AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | GRUPPO LEPETIT S.P.A. (IT) | 1982-07-14 | — | — | EP | disclosed |
| US-4232017-A | CNS DEPRESSANTS; TRANQUILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1980-11-04 | — | — | US | disclosed |
| EP-0005745-A1 | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, CNS-depressant and anti-anxiety agents and pharmaceutical compositions thereof | GRUPPO LEPETIT S.P.A. (IT) | 1979-12-12 | — | — | EP | disclosed |
| US-4113731-A | PHOTOGRAPHIC EMULSION STABILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1978-09-12 | — | — | US | disclosed |