Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.74 |
| ▸ | GAA | P10253 | 11/20 | 0.74 |
| ▸ | MEN1 | O00255 | 11/20 | 0.74 |
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | LMNA | P02545 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | APAF1 | O14727 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10085969 | 0.92 | KMT2A (0.87) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL10086015 | 0.90 | KMT2A (0.84) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL3395971 | 0.85 | KMT2A (1.00) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL4159123 | 0.84 | KMT2A (0.74) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL10084915 | 0.84 | GAA (0.74) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL11874703 | 0.84 | KMT2A (0.74) | KMT2AGAAMEN1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL11862709 | 0.84 | KMT2A (0.97) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL11273709 | 0.84 | KMT2A (0.64) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL15018298 | 0.83 | KMT2A (0.77) | KMT2AGAAMEN1MAPTLMNA | |
| SCHEMBL10084932 | 0.83 | KMT2A (0.77) | KMT2AGAAMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013023300-A1 | INHIBITORS OF ANDROGEN RECEPTOR ACTIVATION FUNCTION-2 (AF2) AS THERAPEUTICS AND METHODS FOR THEIR USE | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2013-02-21 | — | — | WO | disclosed |
| EP-0002906-B1 | NOVEL PERIMIDINES, THEIR PREPARATION, FORMULATIONS AND USE AS IMMUNOSUPPRESSIVES | ELI LILLY AND COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |
| EP-0002906-A2 | Novel perimidines, their preparation, formulations and use as immunosuppressives | ELI LILLY AND COMPANY (US) | 1979-07-11 | — | — | EP | disclosed |