Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11307009 | 0.96 | ABCB1 (0.47) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL15174189 | 0.80 | ABCB1 (0.55) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL1101904 | 0.78 | KDM4E (0.55) | ABCB1ACHEKMT2AMEN1KDM4E | |
| SCHEMBL26660095 | 0.77 | KMT2A (0.49) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL13777930 | 0.77 | KMT2A (0.46) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL25552838 | 0.77 | KMT2A (0.47) | ABCB1ACHEKMT2AKDM4EGAA | |
| SCHEMBL24359163 | 0.74 | KDM4E (0.53) | ACHEKMT2AMEN1MAPK1BPTF | |
| SCHEMBL4908625 | 0.73 | KMT2A (0.43) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL857098 | 0.73 | KMT2A (0.46) | ABCB1ACHEKMT2AMEN1MAPK1 | |
| SCHEMBL3563842 | 0.73 | KDM4E (0.63) | ACHEKMT2AMEN1MAPK1BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339503-B2 | Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors | MERCK PATENT GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-9339503-B2 | Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors | MERCK PATENT GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-9339503-B2 | Tetrahydro-quinazolinone derivatives as TANK and PARP inhibitors | MERCK PATENT GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| EP-2812323-B1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| EP-2812323-B1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | disclosed |
| EP-2812323-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | Merck Patent GmbH (DE) | 2014-12-17 | — | — | EP | disclosed |
| WO-2013117288-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | WO | disclosed |
| WO-2013117288-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | WO | disclosed |
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0022481-A1 | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions | Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) | 1981-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025071-A1 | TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS | TNKS, PARP1, PARP11 | ABCB1 665/4885ACHE 3055/4885KMT2A 1590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.